Carprofen is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) with characteristic analgesic and antipyretic activity.
As with other NSAIDs, the exact mode of action of carprofen has not been established. However, inhibition of prostaglandin synthesis accounts for at least part of its mechanism of action. Carprofen is a moderately potent inhibitor of phospholipase A2 and a reversible inhibitor of cyclooxygenase.
Carprofen is rapidly and nearly completely absorbed when administered orally. Peak blood plasma concentrations are achieved in one to three hours after oral administration to dogs. The mean terminal half-life is approximately eight hours after single oral doses. After a single intravenous bolus dose of 100 mg, the mean elimination half-life was approximately 11.7 hours in the dog.
- Carprofen 20 mg, 50 mg.
A non-steroidal anti-inflammatory drug for the relief of pain and inflammation in dogs.