Buprelieve

Buprelieve

Buprelieve is used in practice for its potentiation of sedation in dogs and horses, and postoperative analgesic effects in dogs, cats and horses.

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SPC
Buprelieve SPC

Active Constituents

Buprenorphine 0.3 mg as buprenorphine hydrochloride

Indications

  • Post-operative analgesia in the dog and cat via intramuscular or intravenous injection.
  • Post-operative analgesia in the horse via intravenous injection only.
  • Potentiation of the sedative effects of centrally-acting agents in the dog and horse.
  • When used in horses for potentiation of sedation, an intravenous sedative should be administered within five minutes prior to injection of buprenorphine.

Prescribing Summary

Buprelieve should be given pre-operatively as part of a premedication protocol, to ensure adequate analgesia upon recovery.

  • Signs of sedation normally appear by 15 minutes post injection. 
  • Analgesic effects in dogs and cats appear around 30 minutes, with peak effects at about 1 – 1.5 hours
  • In horses, analgesic effects occur during the first 15 – 30 minutes post injection, with peak effects occurring between 45 minutes and 6 hours after administration

Use with other agents

The mild sedative effects of buprenorphine can be potentiated by other centrally acting agents such as tranquillisers, sedatives and hypnotics.
Buprelieve can be used with common sedatives and induction agents including:

  • Acepromazine
  • Alfaxalone
  • Atropine
  • Alpha 2 agonists*
  • Isoflurane & sevoflurane
  • Ketamine
  • Propofol

Please note when used in combination with sedatives, the depressive effects on heart rate and respiration may be augmented.
*(medetomidine, dexmedetomidine, detomidine, romifidine and xylazine)

Dosage

Dog & Cat Dosage

To ensure analgesia is present during surgery and immediately on recovery, administer at least 30 minutes pre-operatively via intramuscular or intravenous injection.

Dogs: for further pain relief, repeat if necessary after 3-4 hours with 10 micrograms per kg or 5-6 hours with 20 micrograms per kg.
Cats: Repeat if necessary, once, after 1-2 hours.

Dog
For post operative analgesia and for potentiation of sedation		 Cat
For post-operative analgesia
Weight (kg) Volume (ml) Weight (kg) Volume (ml)
1 0.06 0.5 0.03
2 0.13 1 0.06
3 0.2 1.5 0.1
4 0.26 2 0.13
5 0.33 2.5 0.16
6 0.4 3 0.2
7 0.46 3.5 0.23
8 0.53 4 0.26
9 0.6 4.5 0.3
10 0.66 5 0.33
15 1 5.5 0.36
20 1.33 6 0.4
25 1.66 6.5 0.44
30 2 7 0.46
35 2.33 7.5 0.5
40 2.66 8 0.53
45 3 8.5 0.56
50 3.33 9 0.6
55 3.66    
60 4    

 

Horse Dosage

 

In horses, an IV sedative should be administered within 5 minutes prior to injection of Buprelieve.

For Post-operative Analgesia
Recommended dose: 10 micrograms per kilogram body weight		 For Potentiation of Sedation
Recommended dose: 5 micrograms per kilogram body weight
Weight (kg) Volume (ml) Weight (kg) Volume (ml)
50 1.66 50 0.83
100 3.33 100 1.66
150 5 150 2.5
200 6.66 200 3.33
250 8.33 250 4.16
300 10 300 5
400 13.3 400 6.66
500 16.6 500 8.33
600 20 600 10
700 23.3 700 11.6
800 26.6 800 13.3
900 30 900 15