The 1950’s witnessed the first use of Acepromazine in humans. Of all veterinary premedications, acepromazine is one of the longest in clinical use. By classification, acepromazine is considered a phenothiazine due to its chemical structure.  Its most notable contributions to veterinary medicine are as a sedative.  

Acepromazine (Ace) is manufactured as a tablet or as an injectable solution for intramuscular, intravenous or subcutaneous administration. In dogs, peak intramuscular sedative effects are seen within 30 minutes; a 2-3 hour duration can be expected29. “Ace” has the ability to reduce inhalant requirement30 and reduce arterial blood pressure via vasodilation31

When administered prior to morphine or hydromorphone, acepromazine helps reduce the incidence of vomiting32.(4) Clinically, utilizing an appropriate dose of acepromazine in the premedication protocol or as a post-surgery sedative is known to promote a smoother recovery.  Acepromazine is metabolized by the liver and excreted in the urine.