The pharmacokinetics of Alfaxan Multidose
After a single dose of Alfaxan Multidose, alfaxalone is metabolized rapidly in the liver and eliminated in the bile and urine, with the drug being completely cleared from the body within a few hours after administration.29 Table 1 shows the phamacokinetic parameters of alfaxalone in both dogs and cats after a single dose administered at the clinically recommended dose rate.30
Parameter |
Dog (n=8) |
Cat (n=8) |
---|---|---|
Mean volume of distribution at steady state |
2.0 L/kg |
1.3 L/kg |
Mean terminal plasma elimination half life |
34 minutes |
43 minutes |
Mean total body clearance |
59.4 mL/kg/min |
24.0 mL/kg/min |
The administration of Alfaxan Multidose to debilitated patients or patients with renal disease, hepatic disease or cardiorespiratory disease has not been evaluated. Doses may need adjustment for geriatric or debilitated patients. Caution should be used in cats or dogs with cardiac, respiratory, renal or hepatic impairment, or in hypovolemic or debilitated cats and dogs and geriatric animals.